Melanotic Macules, Naevi, and Melanoma Springer Nature Link What Caused These Multiple Hyperpigmented Macules of the Mouth? Tiny brown spot on the lip? Don't ignore it. A melanotic macule is a small, well circumscribed brown to black oral lesion most commonly seen on the lower lip and a high yield ADC exam favourite. 1 COMPREHENSIVE OVERVIEW OF ORAL PATHOLOGY Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome