The Consequences of Valproate Overdose Valproic Acid Intoxication EMCrit Project Valproic Acid Toxicity When the calmer becomes the culprit In the ICU, some tox cases whisper and some unravel like a metabolic domino cascade. Valproate toxicity belongs to the latter. Targeting Skeletal Muscle Dysfunction With L Carnitine for the Treatment of Patients With Chronic Obstructive Pulmonary Disease In Vivo Valproate Induced Encephalopathy Presenting at Therapeutic Blood Concentrations: A Case Report and Literature Review