The Difference Between Moles, Freckles, and Cancerous Spots Spot the Difference: Are Those Adorable Freckles or Unwanted Age Spots? Blog Face Forward Medical Aesthetics Sooo this feels vulnerable to share. I've been taking a very small dose of Melanotan 2 peptide to help build a tan and the last few days I've worn zero Freckles develop when specific skin cells produce extra melanin in response to sunlight. When ultraviolet rays reach the skin, melanocytes release melanin to protect deeper layers from damage. In some people, certain Sun Spots vs Freckles on Dark Skin What's the Difference? BGS