Cagrilintide 10mg Long Acting Amylin Analog Midwest Peptide Once weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double blind, placebo controlled and active controlled, dose finding phase 2 trial The Lancet Weight Loss Efficacy of Cagrilintide and Semaglutide gutsandgrowth In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3 eBioMedicine