Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Tylenol depletes something called glutathione. Glutathione is a master antioxidant and your first line of protection against environmental toxins. It detoxifies and protects your cells. It protects your immune system and Sex differences in glutathione metabolism and acetaminophen toxicity Acetaminophen (Paracetamol) Journal of Pain and Symptom Management Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation