Acetaminophen Pathway (toxic doses), Pharmacokinetics Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Taking Tylenol? The Glutathione Connection Dr. Green Mom Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Can I give Tylenol (acetaminophen) to a patient with elevated aspartate aminotransferase (AST) alanine aminotransferase (ALT) levels?