Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health They told us Tylenol is safe. Pediatricians recommend them daily. But what if we've been missing the full story? Research shows that frequent use of acetaminophen (Tylenol) in babies and children