Acid Reducers Affect More Than Heartburn Proton pump inhibitors can be effective, but long term use changes how the body handles nutrients, microbes, and infection risk. Which is why its important the benefit GERD Diet: Foods to avoid, what to eat, and plans for acid reflux 7 Drugs and 6 Supplements that Cause Heartburn Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes npj Metabolic Health and Disease Frontiers The role of the esophageal and intestinal microbiome in gastroesophageal reflux disease: past, present, and future