Tylenol's Impact on Glutathione and Liver Damage Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Tylenol Glutathione Kizer Wellness LLC Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports