Frontiers Glucose 6 Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz G6PD enzyme mechanism and relationship with hydrogen peroxide Download Scientific Diagram Glucose 6 Phosphate Dehydrogenase