Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Acetaminophen metabolism Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen toxicity EMCrit Project