Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5 oxoproline accumulation: an under diagnosed phenomenon BMJ Case Reports How do glutathione and Nacetylcysteine (NAC) compare regarding indications, dosing, effectiveness, and safety for acetaminophen toxicity, mucolytic therapy, and general antioxidant supplementation? Acetaminophen, ethanol and other co ingestions ScienceDirect