Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species Antimicrobial Agents and Chemotherapy The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment: Cell Thiol based redox metabolism of protozoan parasites ScienceDirect Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Reductive Activation of Artefenomel (OZ439) by Fe(II) Heme, Related to Its Antimalarial Activity ACS Infectious Diseases